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Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients.
Part 1. New Roles for Sphingolipid Signaling and Cell Function.- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.- 2. Exploring the Therapeutic Landscape of Sphingomyelinases.- 3. Sphingosine kinases as druggable targets.- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease.- 4. Prospects for PLD inhibition in cancer and thrombotic disease.- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer.- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease.- Part 3. Lipid Kinases and Novel Regulatory Pathways.- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.- 8. Functions of Nuclear Polyphosphoinositides.- Part 4. Bioactive Lipids in Health and Disease.- 9. Platelet-Activating Factor as an Effector for Environmental Stressors.- 10. Phospholipase D and Choline Metabolism.- Part 5- Lipids and Membrane Microdomains.- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology.- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs.- Part 6. Nuclear Trafficking of Lipids.- 13. Inositide-Dependent Nuclear Signalling in Health and Disease.- 14. Lipids in Exosome Biology.
