Integrative Approaches in Stem Cell and Tissue Engineering

R. C. Sobti is an Emeritus Professor and Indian National Science Academy (INSA) senior scientist at Punjab University. He is a former of Vice-Chancellor Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and subsequently used modern technologies of molecular biology, like genomics for understanding the susceptibility and disease process of cancer, COPD, AIDS metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 300 papers in the journals of international repute and has also published more than 40 books.He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases, and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration, and Sriram Oration Awards, and of Lifetime Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.Aastha Sobti, BDS, MClinDent, PhD is a Postdoctoral Research Fellow at the University of Pittsburgh and UPMC Hillman Cancer Center, specializing in computational approaches to head and neck cancer biology. She earned her PhD in Onco-Immunology with honors from Lund University, Sweden (2023) under the Marie Skłodowska-Curie COFUND program, and holds an MClinDent with distinction from University College London (2015). Dr. Sobti's research integrates artificial intelligence, genomics, and experimental biology for precision medicine applications in cancer. She has published over 10 papers in leading journals and received prestigious awards, including the SITC Young Investigator Award (2024), VINNOVA Grant (2022), and Academic Certificate of Excellence from the British Association of Oral Surgeons. With international research experience across four countries and proven success in clinical translation, she brings unique expertise bridging computational innovation with clinical application in oncology.

• SECTION 1: BASIC BIOLOGY OF STEM CELLSChapter 1: Stem Cells, Their Applications, and Future Prospects. Chapter 2: The Cell Theory and Concepts, Their Types and Cell Characteristics. Chapter 3: Cellular Processes: Cell Division, Differentiation, Dedifferentiation, Proliferation, and Apoptosis. Chapter 4: Blueprint of Life: Patterns and Molecular Mechanisms in Embryogenesis Across Model Organisms.SECTION 2: STEM CELL TYPES AND THEIR TECHNICAL ASPECTSChapter 5: Discovery of Stem Cells and Their Types. Chapter 6: Instrumentation and Techniques in Stem Cells Cultures. Chapter 7: Milestones in Animal Cell Culture. Chapter 8: Adult Stem Cells and Applications. Chapter 9: Embryonic Stem Cells, Ethics, Concerns and Applications. Chapter 10: Mechanism of Pluripotency. Chapter 11: Induced Pluripotent Stem Cells: From Discovery to Application. Chapter 12: Editing in the Stem Cells.SECTION 3: STEM CELLS IN BIOMATERIAL AND TISSUE ENGINEERINGChapter 13: Concepts of Tissue Engineering. Chapter 14: Scaffolds in Tissue Engineering. Chapter 15: Emerging Trends in Tissue Engineering: Biomaterials, Scaffolds, and Regenerative Strategies. Chapter 16: Tissue Engineering: Bridging Regenerative Medicine and Cancer Therapy. Chapter 17: Tissue Constructs in Functional Tissue Engineering.SECTION 4: STEM CELL IN BIOMANUFACTURING AND PRECISION MEDICINEChapter 18: Organoids in Medicine. Chapter 19: Organ-on-a-Chip and Metabolomics: Converging Technologies for Translational Research. Chapter 20: Stem Cells and Bioprinting. Chapter 21: Advances in Bioprinting for Precision Medicine.SECTION 5: APPLICATIONS IN REGENERATIVE MEDICINE AND CANCERChapter 22: Current Trends and Futuristic Scope of Stem Cells. Chapter 23: Rewriting Life: Implication of Stem Cells and Their Medicine Promise. Chapter 24: Stem Cells in Regenerative and Molecular Medicine. Chapter 25: Industrial Approaches to Regenerative Medicine. Chapter 26: Understanding Cancer Stem Cells: From Tumor Initiation to Therapeutic Targeting. Chapter 27: The Biology of Adult Stem Cells and Their Significance in Cancer: Overview. Chapter 28: Scaffolds in Cancer Research: Bridging Tumor Microenvironment Replication and Therapeutic Advancements.SECTION 6: REGULATORY MECHANISMS AND POLICYChapter 29: Regulatory Aspects in Stem Cell Research.