In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity 1

Kropp & själ

In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity

Rakesh Jagtap • Harun Patel • Kiran Dhangar

Pocket

769:-

Funktionen begränsas av dina webbläsarinställningar (t.ex. privat läge).

Uppskattad leveranstid 7-11 arbetsdagar

Fri frakt för medlemmar vid köp för minst 249:-

56 sidor
2015

Over expression of 11-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 -HSD 1 analog of corosolic acid without nephrotoxicity.

Författare: Rakesh Jagtap, Harun Patel, Kiran Dhangar
Format: Pocket/Paperback
ISBN: 9783659790010
Språk: Engelska
Antal sidor: 56
Utgivningsdatum: 2015-10-20
Förlag: LAP Lambert Academic Publishing