Health Promotion and Aging

The major hormone produced by the adrenal gland is dehydroepiandrosterone (DHEA). The production of this hormone declines with age. The goal of this study is to describe what is known about the role of reduced levels of DHEA in diseases of old age. The research agenda of the US National Institute of Aging is looked at, bringing into focus the areas where information is still scarce. Following this, experts have reviewed and analyzed information on the role of DHEA in modulation of fat and muscle, bone damage, Alzheimer's disease, heart disease, cancer, fertility and sexuality. In addition, the role of DHEA in children's growth and development is appraised, and there is a discussion on chemical analogues, which may have special activities.