Endocrine Therapy in Breast Cancer

This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. "Endocrine Therapy in Breast Cancer" details modern techniques for molecular profiling, monitoring, and targeting; offers methods to identify high-risk groups; evaluates molecular biomarkers in breast cancer assessment; examines the potential toxicity of estrogen receptor (ER)-directed endocrine therapy; investigates the development of endocrine resistance; discusses neoadjuvant and preoperative approaches in patient care; reviews mechanisms that lead to estrogen-independent phenotypes. Surveying the medical, surgical, and pathological aspects of endocrine therapy, as well as future research opportunities, "Endocrine Therapy in Breast Cancer" is a concise and in-depth manual for medical, surgical, and radiation oncologists; endocrinologists; gynecologists; obstetricians; pharmacologists; family physicians; reproductive biologists; epidemiologists; and medical school students.