Effect of Bean Extract (Phaseolus vulgaris L) to LDL and Ox-LDL and Relation of Ox-LDL on LOX-1 Gene Polymorphism 3'UTR

Cardiovascular disease is the leading cause of death in most developed countries. Atherosclerosis, a blockage of the arteries, is the result combination of abnormalities lipoprotein metabolism, oxidative stress, chronic inflammation and the possibility for the occurrence of thrombosis. This whole process will play a role in the onset of cardiovascular disease. Most deaths from cardiovascular disease can be prevented through lifestyle changes such as diet, exercise, and stop smoking. Initial event in atherosclerosis is change low density lipoprotein (LDL) into oxidized low density lipoprotein (Ox-LDL). Activity of oxidized LDL mediated by different receptors called scavenger receptor (SR), such as lectin-like oxidized low-density lipoprotein receptor-1 (LOX- 1). There are 7 polymorphisms that have been identified in the LOX-1 gene. One is 3'UTR188C/T. Decrease input saturated fat; cholesterol and increased input of cholesterol-lowering foods such as nuts should be given priority as prevention for cardiovascular disease. Beans (Phaseolus vulgaris L) are a type of legume. Dry beans have also been shown to improve serum lipid profile in patients with coronary heart disease.