Doxorubicin Induced Cardiotoxicity

Doxorubicin/Adriamycin (Dox) is a powerful, well established and highly efficacious drug in the fight against many kinds of cancers like solid tumors, leukemia's, soft tissue sarcoma, breast cancer, small cell carcinoma of the lung and esophageal carcinomas. But its clinical usefulness is still restricted due to its specific toxicities to cardiac tissues. Congestive heart failure, cardiomyopathy, and electrocardiographic changes were demonstrated after cumulative Dox administration.The possible mechanisms proposed for cardiotoxic effects of Doxorubicin include free radical induced myocardial injury, lipid peroxidation, mitochondria damage, decreased activity of Na, K-adenosine triphosphate, vasoactive amine release, impairment in myocardial adrenergic signaling/regulation and cellular toxicity. The present book will reveal the role of common spice on biochemical alterations and oxidative status against Doxorubicin/adriamycin induced cardiotoxicity.