Diabete sucre de type 2, stress oxydatif et deficiences visuelles

To determine the natural history of visual deficiencies due to type 2 diabetes mellitus challenging with oxidant/antioxidant imbalance. We conducted cross-sectional, case-control, and cohort studies from hospital and community-based surveys. There were 50 controls non diabetics and 1094 type 2 diabetics. Short diabetes mellitus duration (<5 years in 50% cases) and aging ( 60 years) were associated with vd. we found 100% of no control of diabetes mellitus and deficiency in vitamin c, 99.3%, 98.7%, 83.3%, 79.3%, 71.8%, and 63.3% of deficiencies in vitamin d, e, zinc, total antioxidant capacity, gluthation peroxidase, and selenium respectively. vd were associated with high levels of thiobarbituric acid (87.7%), guanosine (76%), 8-isoprostane (74.7%), ggt (6.7%), and oxidized-ldl (63.3%). frequency of vd increased with proportion of phenotypes of dr defined by macular edema: 62.7% (n=84/134) in absence of dr and macular edema, 100% (n=35/35) in isolated dr, and 100% (n=31/31) in combined dr + macular edema phenotype. vd in bantu type 2 diabetics showed a new biomolecular phenotype charactezised by oxidative stress.