Kropp & själ
Pocket
Controlled Drug Delivery of Hydrophobic Drug
Rajesh Jagtap • Sneha Jagtap • Sandeep Chavan
1049:-
Uppskattad leveranstid 7-11 arbetsdagar
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Glipizide, an oral hypoglycemic agent, is one of the most commonly prescribed drugs for the treatment of patients with type II diabetes mellitus. It is practically water-insoluble, thus it belongs to class-II of Biopharmaceutical Classification System (BCS). Glipizide has a relatively short elimination half-life (2-4 h), thereby requiring twice daily dosing in large number of patients, which often leads to non-compliance. Thus, there is a strong clinical need and market potential for a dosage form that will deliver glipizide in a controlled manner to a patient needing this therapy, thereby resulting in a better patient compliance. The aim of present investigation was to enhance the solubility by using -cyclodextrin binary complexation and impart a controlled release in a single formulation in order to reduce dosing frequency.
- Format: Pocket/Paperback
- ISBN: 9786202518062
- Språk: Engelska
- Antal sidor: 96
- Utgivningsdatum: 2020-03-27
- Förlag: LAP Lambert Academic Publishing