Comparative study of Fasting and postprandial dyslipidemia in Type2 DM

Type 2 Diabetes Mellitus (DM) is characterized by insulin resistance which is associated with glucose intolerance, hypertension, dyslipidaemia, a procoagulant state, and an increase in the microvascular and the macrovascular disease. Diabetics are frequently hyperlipidemic and they are at a high risk for coronary heart disease. The high cardiovascular mortality which is associated with Type 2 DM is due to a prolonged, exaggerated, postprandial state. The postprandial dysmetabolism and the associated oxidative stress may link the insulin resistance and the Type 2 DM to the disproportional incidence of cardiovascular disease. Postprandial hypertriglyceridaemia has been linked to asymptomatic and symptomatic macrovascular diseases in both normo or hypertriglyceridaemic subjects and such abnormalities have been reported in the type 2 diabetics. The increased risk of atherosclerosis among them, may therefore, be related to the higher postprandial lipaemia in them. The postprandial dysmetabolism and the associated oxidative stress may link the insulin resistance and the Type 2 DM to the disproportional incidence of cardiovascular disease.