Catalytic Asymmetric Radical Reactions

Inbunden, Engelska, 2025

Av Xin-Yuan Liu, Guosheng Liu, China) Liu, Xin-Yuan (Southern University of Science & Technology, China) Liu, Guosheng (Shanghai Institute of Organic Chemistry

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Strategies to develop catalytic asymmetric radical reactions, from metal-based methods to organocatalytic systems Catalytic Asymmetric Radical Reactions systematically and comprehensively summarizes the development of different strategies to realize asymmetric radical reactions, from metal-based methods to organocatalytic systems. The book starts with the background introduction of this topic and emphasizes the significance and challenge of the stereocontrol over the radical intermediates. Subsequently, it describes the detailed strategies to realize the asymmetric radical reactions, demonstrating how the design of chiral catalysts and substrates helps to achieve the asymmetric induction. Finally, it summarizes the developed strategies and presents a perspective in future development of asymmetric radical reactions. Catalytic Asymmetric Radical Reactions includes information on: Earth-abundant transition metal (e.g., iron, cobalt, nickel, copper, and manganese)-catalyzed asymmetric radical reactionsPhotoredox/earth-abundant metal-catalyzed asymmetric radical reactions and precious transition metal-catalyzed asymmetric radical reactionsChiral Lewis acid-catalyzed asymmetric radical transformations and chiral-at-metal complex-catalyzed asymmetric radical reactionsOrganocatalysis via covalent bonds and hydrogen bonding for asymmetric radical transformationsCovalent interaction (S/Sn/B-centered radical)-induced asymmetric radical reactionsCatalytic Asymmetric Radical Reactions is a timely reference for researchers in academia and industry working in the fields of organic synthesis, drug discovery, and materials science.

Produktinformation

Utgivningsdatum2025-09-10
Mått170 x 244 x 34 mm
Vikt1 170 g
FormatInbunden
SpråkEngelska
Antal sidor560
FörlagWiley-VCH Verlag GmbH
ISBN9783527350285

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Xin-Yuan Liu is a Chair Professor in the Department of Chemistry at Southern University of Science and Technology, China. He focuses on developing novel chiral anionic ligands in realizing the copper-catalyzed asymmetric radical reactions Currently, he is an associated editor of Synthesis. He has received numerous scientific awards, including the National Distinguished Young Scholar (NSFC), XPLORER prize, Boehringer Ingelheim Lectureship (Boston College), CAPA Distinguished Faculty Award, the Distinguished Lectureship Award from the Chemical Society of Japan, and The 12th CCS-BASF Youth Knowledge Innovation Award. Guosheng Liu is a Professor in Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), China. His research focuses on the highly selective functionalization of alkenes and alkanes, particularly on the site- and enantioselective sp3 C-H functionalization via metal-catalyzed radical relay. Currently, he is an associated editor of Organic Letters. He has received many scientific awards, including the National Distinguished Young Scholar (NSFC), New Cornerstone Investigator Program, Friedrich Wilhelm Bessel Research Award (Alexander von Humboldt Foundation), and The 9th CCS-BASF Youth Knowledge Innovation Award.

Preface1. IntroductionPart I Transition metal catalysis2. Iron catalyzed asymmetric radical reactions3. Cobalt catalyzed asymmetric radical reactions4. Nickel-catalyzed electrophile-nucleophile and related asymmetric radical cross-coupling5. Nickel-catalyzed electrophile-electrophile reductive and related asymmetric radical cross-coupling6. Copper-catalyzed cross-coupling and related asymmetric radical reactions7. Copper-catalyzed asymmetric radical alkene difunctionalization reactions8. Precious transition metal-catalyzed asymmetric radical reactionsPart II Lewis Acid Catalysis9. Metal/chiral ligand-catalyzed asymmetric radical reactions10. Lewis acid catalyzed asymmetric radical [n+2] reactions11. Chiral metal complex-catalyzed asymmetric radical reactionsPart III Organocatalysis12. chiral amine catalysis for asymmetric radical transformations13. Application of chiral phosphoric acids in asymmetric radical transformations14. Hydrogen bonding and other interactions-induced asymmetric radical transformationsPart IV Enzyme and biomimetic asymmetric radical transformation15. Enzyme and biomimetic asymmetric radical transformation