BRCA1/2, PALB2 mutations in breast-ovarian syndrome, our series

Breast cancer in Algeria, and more particularly in the western part of the country, has a particular epidemiological character which contrasts with universal data, due to its incidence in young and even very young patients in a historical context of multiple, multi-organ, transmissible family cancers.Our aim is to report on the overall history of index cases and related cases of breast-ovarian syndrome with BRCA1/BRCA2/PALB2 mutations in 38 young patients at the Sidi Bel Abbés Cancer Centre in Algeria.Our long-term objectives are to categorise the main genetic mutations and to develop a panel of genes specific to the different Algerian ethnic groups.