Biolyuminestsentsiya Fotoproteina Obelina. Kvantovo-Khimicheskoe Opisanie

Biolyuminestsentsiya - yavlenie, shiroko predstavlennoe v prirode. V nastoyashchee vremya biolyuminestsentnye belki yavlyayutsya osnovoy mnogikh shiroko ispol'zuemykh metodov analiza. Biolyuminestsentnye metody shiroko ispol'zuyutsya v kletochnoy biologii i ekologii, a takzhe v meditsinskoy diagnostike i issledovaniyakh onkologicheskikh zabolevaniy. Znachitel'nyy progress v ponimanii mekhanizma biolyuminestsentsii i roli otdel'nykh aminokislot belka v etom protsesse byl dostignut posle opredeleniya neskol'kikh prostranstvennykh struktur fotoproteinov. Tsel'yu kvantovo-khimicheskikh raschetov yavlyaetsya adekvatnoe opisanie real'nykh sistem: tochnyy raschet stroeniya molekul, ikh fiziko-khimicheskikh svoystv, kolichestvennoe predskazanie reaktsionnoy sposobnosti. V dannoy monografii predstavlenno issledovanie protsessa fluorestsentsii Sa-reguliruemogo fotoproteina obelina s pomoshch'yu metodov kvantovo-khimicheskikh raschetov. Rabota vypolnena pri finansovoy podderzhke RFFI (07-04-00930-a), programmy Prezidiuma RAN Molekulyarnaya i kletochnaya biologiya i programmy Sibirskogo otdeleniya RAN (proekt 2), v ramkakh realizatsii FTsP Nauchnye i nauchno-pedagogicheskie kadry innovatsionnoy Rossii na 2010 god (P333 i P213).