Biological Evaluation of Some Chemotherapeutic Agents

Drug/drug interaction is a situation in which a drug, could affect the activity of another drug, i.e. the effects of the drug are increased or decreased, or produces a new effect that neither of them produces on its own. Thereby often the efficacy or toxicity of a medication is changed. Drug/drug interactions could be attributed into pharmacokinetic or pharmacodynamic interaction. Pharmacokinetic interaction: the drug concentration against time curve in the body is modified. Pharmacokinetic interactions can be based on pharmacokinetic parameters of a drug (absorption, distribution, metabolism and elimination). While, pharmacodynamic interaction: the activity of a drug is modified without changes in the drug concentration versus time profile, usually when two (or more drugs) are competitors (physiological or pharmacological) for binding to the same or different receptor(s). Drugs could act by addition, synergistic or antagonistic manners. It is my study to investigate a method for a biological evaluation of chemotherapeutic agents.