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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors 1

bokomslag Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Kropp & själ

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Inbunden

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336 sidor
2010

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
Preclinical models in COMT inhibitor devlopment
Transgenic COMT mice - latest information summarized
Chemistry of COMT inhibitors and their design with molecular modelling
COMT gene and its regulation and relation to dopamine related diseases
Role of cofactor SAM regulation in relation to homocysteine
Nonclinical and clinical safety of COMT inhibitors summarized
Future prospects of COMT inhibitors in Parkinson's disease

Format: Inbunden
ISBN: 9780123813268
Språk: Engelska
Antal sidor: 336
Utgivningsdatum: 2010-12-14
Förlag: Academic Press