An Update on Functional Expression of Recombinant Human Adiponectin

Adiponectin is one of the most bioactive substances secreted by adipose tissue which is involved in protection against metabolic syndrome, artherosclerosis and type II diabetes. Research into the use of adiponectin as a promising drug for metabolic syndromes requires production of this hormone in high quantities. This may be achieved using recombinant DNA technology, which would also allow the production of different molecular forms as well as providing greater input in terms of understanding its signalling pathway. This work describes the functional production of human adiponectin in eukaryotes and prokaryotes for potential application in pharmaceutical therapy.