Vetenskap & teknik
Pocket
A Novel Enantioselective Synthesis of Spiro-Oxindoles
Sesha Sridevi Alluri • Chih-Hung Wang • Michael Bertucci
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Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.
- Format: Pocket/Paperback
- ISBN: 9783838355085
- Språk: Engelska
- Antal sidor: 76
- Utgivningsdatum: 2010-07-06
- Förlag: LAP Lambert Academic Publishing