Sodium Alginate Floating Pellet of Aceclofenac

Aceclofenac floating pellets where prepared by extrusion spheronization method and the drug-released profile of aceclofenac was investigated. Different batches of pellets were prepared by using sodium alginate and HPMC K4M, HPMC K100LV as polymer. In vitro dissolution of pellets was carried out in USP apparatus XXIV (paddle method) at 50rpm.The drug release was measured by using UV spectroscopy of max of 273nm for acid buffer media. The dissolution data were treated with zero order, first order and Higuchi model. Half of the formulations were fitted to Higuchi model and to the first order model. Finally it can be concluded that with the increasing polymer concentration to optimum level the release rate of Aceclofenac was satisfactory but further increased causes decreased of Aceclofenac release.